Tailoring T-cell receptor signals by proximal negative feedback mechanisms.
The T-cell receptor (TCR) signalling machinery is central in determining the response of a T cell (establishing immunity or tolerance) following exposure to antigen. This process is made difficult by the narrow margin of self and non-self discrimination, and by the complexity of the genetic programm...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2008
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