Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A.
Neutrophils are the main effector cells during inflammation, but they can also control excessive inflammatory responses by secreting anti-inflammatory cytokines. However, the mechanisms that modulate their plasticity remain unclear. We now show that systemic serum amyloid A 1 (SAA-1) controls the pl...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2010
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| _version_ | 1797062878864343040 |
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| author | De Santo, C Arscott, R Booth, S Karydis, I Jones, M Asher, R Salio, M Middleton, M Cerundolo, V |
| author_facet | De Santo, C Arscott, R Booth, S Karydis, I Jones, M Asher, R Salio, M Middleton, M Cerundolo, V |
| author_sort | De Santo, C |
| collection | OXFORD |
| description | Neutrophils are the main effector cells during inflammation, but they can also control excessive inflammatory responses by secreting anti-inflammatory cytokines. However, the mechanisms that modulate their plasticity remain unclear. We now show that systemic serum amyloid A 1 (SAA-1) controls the plasticity of neutrophil differentiation. SAA-1 not only induced anti-inflammatory interleukin 10 (IL-10)-secreting neutrophils but also promoted the interaction of invariant natural killer T cells (iNKT cells) with those neutrophils, a process that limited their suppressive activity by diminishing the production of IL-10 and enhancing the production of IL-12. Because SAA-1-producing melanomas promoted differentiation of IL-10-secreting neutrophils, harnessing iNKT cells could be useful therapeutically by decreasing the frequency of immunosuppressive neutrophils and restoring tumor-specific immune responses. |
| first_indexed | 2024-03-06T20:51:54Z |
| format | Journal article |
| id | oxford-uuid:37e0812f-ed4e-429c-951e-d2dd266040d8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:51:54Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:37e0812f-ed4e-429c-951e-d2dd266040d82022-03-26T13:46:37ZInvariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:37e0812f-ed4e-429c-951e-d2dd266040d8EnglishSymplectic Elements at Oxford2010De Santo, CArscott, RBooth, SKarydis, IJones, MAsher, RSalio, MMiddleton, MCerundolo, VNeutrophils are the main effector cells during inflammation, but they can also control excessive inflammatory responses by secreting anti-inflammatory cytokines. However, the mechanisms that modulate their plasticity remain unclear. We now show that systemic serum amyloid A 1 (SAA-1) controls the plasticity of neutrophil differentiation. SAA-1 not only induced anti-inflammatory interleukin 10 (IL-10)-secreting neutrophils but also promoted the interaction of invariant natural killer T cells (iNKT cells) with those neutrophils, a process that limited their suppressive activity by diminishing the production of IL-10 and enhancing the production of IL-12. Because SAA-1-producing melanomas promoted differentiation of IL-10-secreting neutrophils, harnessing iNKT cells could be useful therapeutically by decreasing the frequency of immunosuppressive neutrophils and restoring tumor-specific immune responses. |
| spellingShingle | De Santo, C Arscott, R Booth, S Karydis, I Jones, M Asher, R Salio, M Middleton, M Cerundolo, V Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A. |
| title | Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A. |
| title_full | Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A. |
| title_fullStr | Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A. |
| title_full_unstemmed | Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A. |
| title_short | Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A. |
| title_sort | invariant nkt cells modulate the suppressive activity of il 10 secreting neutrophils differentiated with serum amyloid a |
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