Copy number, linkage disequilibrium and disease association in the FCGR locus.

The response of a leukocyte to immune complexes (ICs) is modulated by receptors for the Fc region of IgG (FcgammaRs), and alterations in their affinity or function have been associated with risk of autoimmune diseases, including systemic lupus erythematosus (SLE). The low-affinity FcgammaR genomic l...

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Detalles Bibliográficos
Main Authors: Niederer, H, Willcocks, L, Rayner, T, Yang, W, Lau, Y, Williams, T, Scott, J, Urban, B, Peshu, N, Dunstan, S, Hien, T, Phu, N, Padyukov, L, Gunnarsson, I, Svenungsson, E, Savage, C, Watts, R, Lyons, P, Clayton, D, Smith, K
Formato: Journal article
Idioma:English
Publicado: 2010