Combined nucleobase and backbone modifications enhance DNA duplex stability and preserve biocompatibility

Combined nucleobase and backbone modifications enhance DNA duplex stability and preserve biocompatibility

DNA strands containing a triazole linkage flanked on its 3′-side by an aminoethylphenoxazine nucleobase analogue (G-clamp) have been prepared by solid-phase synthesis followed by CuAAC-mediated click oligonucleotide ligation. The stability of the doubly modified DNA duplexes and DNA-RNA hybrids is g...

書誌詳細
主要な著者:	El-Sagheer, A, Brown, T
フォーマット:	Journal article
出版事項:	Royal Society of Chemistry 2014

類似資料

Enhanced H-bonding and pi-stacking in DNA: a potent duplex-stabilizing and mismatch sensing nucleobase analogue
著者:: Lou, C, 等
出版事項: (2014)

Molecular requirements of high-fidelity replication-competent DNA backbones for orthogonal chemical ligation.
著者:: Shivalingam, A, 等
出版事項: (2017)

Assessing the biocompatibility of click-linked DNA in Escherichia coli.
著者:: Sanzone, A, 等
出版事項: (2012)

RNAfitme: a webserver for modeling nucleobase and nucleoside residue conformation in fixed-backbone RNA structures
著者:: Maciej Antczak, 等
出版事項: (2018-08-01)

Biocompatible artificial DNA linker that is read through by DNA polymerases and is functional in Escherichia coli.
著者:: El-Sagheer, A, 等
出版事項: (2011)

NMR analyses on N-hydroxymethylated nucleobases - implications for formaldehyde toxicity and nucleic acid demethylases
著者:: Shishodia, S, 等
出版事項: (2018)

The stability of triplex DNA is affected by the stability of the underlying duplex.
著者:: Rusling, D, 等
出版事項: (2009)

Structure and dynamics of triazole-linked DNA: biocompatibility explained.
著者:: Dallmann, A, 等
出版事項: (2011)

Selective Sensing of DNA Nucleobases with Angular Discrimination
著者:: Laith A. Algharagholy, 等
出版事項: (2024-01-01)

Searching for the ideal triazole: investigating the 1,5-triazole as a charge neutral DNA backbone mimic
著者:: Baker, YR, 等
出版事項: (2019)

DNA duplexes stabilized by modified monomer residues: synthesis and stability
著者:: Graham, D, 等
出版事項: (1998)

Enhanced Stability of DNA Oligonucleotides with Partially Zwitterionic Backbone Structures in Biological Media
著者:: Melissa Meng, 等
出版事項: (2018-11-01)

Biocompatible organic–inorganic hybrid materials based on nucleobases and titanium developed by molecular layer deposition
著者:: Leva Momtazi, 等
出版事項: (2019-02-01)

Design of thiazole orange oligonucleotide probes for detection of DNA and RNA by fluorescence and duplex melting
著者:: Klimkowski, P, 等
出版事項: (2019)

Assembly of a biocompatible triazole-linked gene by one-pot click-DNA ligation
著者:: Kukwikila, M, 等
出版事項: (2017)

Biological nanopore approach for single‐molecule analysis of nucleobase modifications
著者:: Pengrui Lv, 等
出版事項: (2022-10-01)

Epigenetic Marks, DNA Damage Markers, or Both? The Impact of Desiccation and Accelerated Aging on Nucleobase Modifications in Plant Genomic DNA
著者:: Beata P. Plitta-Michalak, 等
出版事項: (2022-05-01)

Exploring the binding pockets of the DNA damage repair enzyme SNM1A through nucleobase modification
著者:: Ellen M. Fay, 等
出版事項: (2023-01-01)

Dual Functionality of 6‑Methylthioguanine: Synergistic Effects Enhancing the Photolability of DNA Nucleobases
著者:: Qian Zhou, 等
出版事項: (2024-01-01)

Hydroxylation of methylated CpG dinucleotides reverses stabilisation of DNA duplexes by cytosine 5-methylation.
著者:: Thalhammer, A, 等
出版事項: (2011)

Synthesis and Properties of Oligonucleotides Containing LNA-Sulfamate and Sulfamide Backbone Linkages
著者:: Zengin Kurt, B, 等
出版事項: (2024)

Dynamic Full-Duplex Cellular System for Wide Area IoT Network Backbone
著者:: Keiichi Mizutani, 等
出版事項: (2024-01-01)

MISMATCHES IN DNA DUPLEXES
著者:: Brown, T, 等
出版事項: (1993)

Influence of Combinations of Lipophilic and Phosphate Backbone Modifications on Cellular Uptake of Modified Oligonucleotides
著者:: Timofey D. Zharkov, 等
出版事項: (2024-01-01)

Enzyme-free synthesis of cyclic single-stranded DNA constructs containing a single triazole, amide or phosphoramidate backbone linkage and their use as templates for rolling circle amplification and nanoflower formation
著者:: Chen, J, 等
出版事項: (2018)

p‑Type Sensing of DNA Nucleobases Adsorbed on Graphene Nanoribbon
著者:: Tianhao Lian, 等
出版事項: (2024-12-01)

Structure and stability of different triplets involving artificial nucleobases: clues for the formation of semisynthetic triple helical DNA
著者:: N. R. Jena, 等
出版事項: (2023-11-01)

Mechanistic Basis for Ribosomal Peptide Backbone Modifications
著者:: Shi-Hui Dong, 等
出版事項: (2019-04-01)

Distinction of nucleobases – a tip-enhanced Raman approach
著者:: Regina Treffer, 等
出版事項: (2011-09-01)

Nucleobase recognition in ssDNA at the central constriction of the alpha-hemolysin pore.
著者:: Stoddart, D, 等
出版事項: (2010)

Nonadiabatic Absorption Spectra and Ultrafast Dynamics of DNA and RNA Photoexcited Nucleobases
著者:: James A. Green, 等
出版事項: (2021-03-01)

Hyperpolarizing DNA Nucleobases via NMR Signal Amplification by Reversible Exchange
著者:: Bryce E. Kidd, 等
出版事項: (2023-01-01)

Covalently attached intercalators restore duplex stability and splice-switching activity to triazole-modified oligonucleotides
著者:: Dysko, A, 等
出版事項: (2022)

An artificial triazole backbone linkage provides a split-and-click strategy to bioactive chemically modified CRISPR sgRNA
著者:: Taemaitree, L, 等
出版事項: (2019)

A General Method for Quantifying Sequence Effects on Nucleobase Oxidation in DNA
著者:: Margolin, Yelena, 等
出版事項: (2011)

Recommendations for Standardized Description of and Nomenclature Concerning Oxidatively Damaged Nucleobases in DNA
著者:: Cooke, Marcus S., 等
出版事項: (2012)

Correlation between polar surface area and bioferroelectricity in DNA and RNA nucleobases
著者:: Yam, See Chuan, 等
出版事項: (2018)

Nucleobase-Modified Microgels Synthesized via Microfabrication Technology for DNA Adsorption
著者:: Kemal Çetin
出版事項: (2023-12-01)

Quantum Simulation of the Silicene and Germanene for Sensing and Sequencing of DNA/RNA Nucleobases
著者:: Hikmet Hakan Gürel, 等
出版事項: (2021-02-01)

The Validation and Amplification of Random DNA Libraries with Modified Nucleobases for Click-SELEX
著者:: Natalia Komarova, 等
出版事項: (2022-11-01)