Integrity of glycosylation processing of a glycan-depleted trimeric HIV-1 immunogen targeting key B-cell lineages

Broadly neutralizing antibodies (bNAbs) that target the trimeric HIV-1 envelope glycoprotein spike (Env) are tools that can guide the design of recombinant Env proteins intended to engage the predicted human germline precursors of bNAbs (gl-bNAbs). The protein components of gl-bNAb epitopes are ofte...

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Bibliographic Details
Main Authors: Behrens, AJ, Kumar, A, Medina-Ramirez, M, Cupo, A, Marshall, K, Portillo, VM, Harvey, DJ, Ozorowski, G, Zitzmann, N, Wilson, IA, Ward, AB, Struwe, WB, Moore, JP, Sanders, RW, Crispin, M
Format: Journal article
Language:English
Published: American Chemical Society 2018