Spatial separation of Xist RNA and polycomb proteins revealed by superresolution microscopy.
In female mammals, one of the two X chromosomes is transcriptionally silenced to equalize X-linked gene dosage relative to XY males, a process termed X chromosome inactivation. Mechanistically, this is thought to occur via directed recruitment of chromatin modifying factors by the master regulator,...
Main Authors: | Cerase, A, Smeets, D, Tang, Y, Gdula, M, Kraus, F, Spivakov, M, Moindrot, B, Leleu, M, Tattermusch, A, Demmerle, J, Nesterova, T, Green, C, Otte, A, Schermelleh, L, Brockdorff, N |
---|---|
Format: | Journal article |
Language: | English |
Published: |
2014
|
Similar Items
-
hnRNPK Recruits PCGF3/5-PRC1 to the Xist RNA B-Repeat to establish polycomb-mediated chromosomal silencing
by: Pintacuda, G, et al.
Published: (2017) -
A pooled shRNA screen identifies Rbm15, Spen, and Wtap as factors required for Xist RNA-mediated silencing
by: Moindrot, B, et al.
Published: (2015) -
Efficiency of Xist-mediated silencing on autosomes is linked to chromosomal domain organisation.
by: Tang, Y, et al.
Published: (2010) -
Xist Repeats B and C, but not Repeat A, mediate de novo recruitment of the Polycomb system in X chromosome inactivation
by: Wei, G, et al.
Published: (2021) -
Mechanisms of Xist-dependent Polycomb recruitment
by: Almeida, M
Published: (2017)