Trading N and O. Part 3: Synthesis of 1,2,3,4-tetrahydroisoquinolines from alpha-hydroxy-beta-amino esters
All rights reserved.A range of enantiopure 1,2,3,4-tetrahydroisoquinolines have been prepared directly from α-hydroxy-β-amino esters. Activation of the α-hydroxy group upon treatment with Tf2O and 2,6-di-tert-butyl-4-methylpyridine promotes aziridinium formation, which is then followed by rupture of...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Published: |
Elsevier
2016
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