A local sensitivity analysis method for developing biological models with identifiable parameters: Application to cardiac ionic channel modelling

Computational cardiac models provide important insights into the underlying mechanisms of heart function. Parameter estimation in these models is an ongoing challenge with many existing models being overparameterised. Sensitivity analysis presents a key tool for exploring the parameter identifiabili...

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Bibliographic Details
Main Authors: Sher, A, Wang, K, Wathen, A, Maybank, P, Mirams, G, Abramson, D, Noble, D, Gavaghan, D
Format: Journal article
Language:English
Published: 2013