Dual role of CO2/HCO3(-) buffer in the regulation of intracellular pH of three-dimensional tumor growths.

Dual role of CO2/HCO3(-) buffer in the regulation of intracellular pH of three-dimensional tumor growths.

Intracellular pH (pH(i)), a major modulator of cell function, is regulated by acid/base transport across membranes. Excess intracellular H(+) ions (e.g. produced by respiration) are extruded by transporters such as Na(+)/H(+) exchange, or neutralized by HCO(3)(-) taken up by carriers such as Na(+)-H...

Descripció completa

Dades bibliogràfiques
Autors principals:	Hulikova, A, Vaughan-Jones, R, Swietach, P
Format:	Journal article
Idioma:	English
Publicat:	2011

Ítems similars

Temperature dependence of Na+-H+ exchange, Na+-HCO3- co-transport, intracellular buffering and intracellular pH in guinea-pig ventricular myocytes.
per: Ch'en, F, et al.
Publicat: (2003)

Acid-extrusion from tissue: the interplay between membrane transporters and pH buffers.
per: Hulikova, A, et al.
Publicat: (2012)

Sarcolemmal localisation of Na+/H+ exchange and Na+-HCO3- co-transport influences the spatial regulation of intracellular pH in rat ventricular myocytes.
per: Garciarena, C, et al.
Publicat: (2013)

Regulation of intracellular pH in cancer cell lines under normoxia and hypoxia.
per: Hulikova, A, et al.
Publicat: (2013)

Spatial regulation of intracellular pH in multicellular strands of neonatal rat cardiomyocytes.
per: Swietach, P, et al.
Publicat: (2010)

Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths.
per: Swietach, P, et al.
Publicat: (2008)

Importance of intracellular pH in determining the uptake and efficacy of the weakly basic chemotherapeutic drug, doxorubicin.
per: Swietach, P, et al.
Publicat: (2012)

Intracellular carbonic anhydrase activity sensitizes cancer cell pH signaling to dynamic changes in CO2 partial pressure
per: Hulikova, A, et al.
Publicat: (2014)

The role of carbonic anhydrase 9 in regulating extracellular and intracellular ph in three-dimensional tumor cell growths.
per: Swietach, P, et al.
Publicat: (2009)

Intracellular pH regulation in heart.
per: Vaughan-Jones, R, et al.
Publicat: (2009)

Spatial regulation of intracellular pH in the ventricular myocyte.
per: Swietach, P, et al.
Publicat: (2005)

Importance of intracellular pH in determining the uptake and efficacy of the weakly basic chemotherapeutic drug, doxorubicin.
per: Pawel Swietach, et al.
Publicat: (2012-01-01)

pH-Regulated Na(+) influx into the mammalian ventricular myocyte: the relative role of Na(+)-H(+) exchange and Na(+)-HCO Co-transport.
per: Vaughan-Jones, R, et al.
Publicat: (2006)

Facilitation by intracellular carbonic anhydrase of Na-HCO co-transport but not Na/H exchange activity in the mammalian ventricular myocyte
per: Villafuerte, F, et al.
Publicat: (2014)

The chemistry, physiology and pathology of pH in cancer.
per: Swietach, P, et al.
Publicat: (2014)

Spatial aspects of intracellular pH regulation in heart muscle.
per: Vaughan-Jones, R, et al.
Publicat: (2006)

Facilitation by intracellular carbonic anhydrase of Na+–HCO3− co‐transport but not Na+/H+ exchange activity in the mammalian ventricular myocyte
per: Villafuerte, F, et al.
Publicat: (2013)

Facilitation by intracellular carbonic anhydrase of Na+-HCO3 - co-transport but not Na+/H+ exchange activity in the mammalian ventricular myocyte
per: Villafuerte, F, et al.
Publicat: (2014)

Effects of extracellular pH, PCO2 and HCO3- on intracellular pH in isolated type-I cells of the neonatal rat carotid body.
per: Buckler, K, et al.
Publicat: (1991)

Na⁺ ions as spatial intracellular messengers for co-ordinating Ca²⁺ signals during pH heterogeneity in cardiomyocytes.
per: Swietach, P, et al.
Publicat: (2015)

The relationship between intracellular pH and proton mobility in rat and guinea-pig ventricular myocytes
per: Swietach, P, et al.
Publicat: (2005)

Relationship between intracellular pH and proton mobility in rat and guinea-pig ventricular myocytes.
per: Swietach, P, et al.
Publicat: (2005)

New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation
per: Swietach, P, et al.
Publicat: (2010)

New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation.
per: Swietach, P, et al.
Publicat: (2010)

H⁺-activated Na⁺ influx in the ventricular myocyte couples Ca²⁺-signalling to intracellular pH.
per: Garciarena, C, et al.
Publicat: (2013)

Experimental generation and computational modeling of intracellular pH gradients in cardiac myocytes.
per: Swietach, P, et al.
Publicat: (2005)

H+-activated Na+ influx in the ventricular myocyte couples Ca2+-signalling to intracellular pH
per: Garciarena, C, et al.
Publicat: (2013)

H+ ion activation and inactivation of the ventricular gap junction: a basis for spatial regulation of intracellular pH.
per: Swietach, P, et al.
Publicat: (2007)

Spatial Control of pH(i) in the Heart, and Its Influence on the Local Control of Intracellular Ca2+ Signaling
per: Vaughan-Jones, R, et al.
Publicat: (2009)

Local release of caged protons by UV flash photolysis as a means of producing intracellular pH non-uniformity
per: Swietach, P, et al.
Publicat: (2005)

Regulation of tumor pH and the role of carbonic anhydrase 9.
per: Swietach, P, et al.
Publicat: (2007)

Na+/H+ and HCO3-/Cl- exchange in the control of intracellular pH in vivo in the spontaneously hypertensive rat.
per: Syme, P, et al.
Publicat: (1991)

The modulation of intracellular pH in carotid body glomus cells by extracellular pH and pCO2.
per: Buckler, K, et al.
Publicat: (1993)

Intracellular proton mobility and buffering power in cardiac ventricular myocytes from rat, rabbit, and guinea pig.
per: Zaniboni, M, et al.
Publicat: (2003)

Effects of extracellular metabolic acidosis and out-of-equilibrium CO2/HCO3− solutions on intracellular pH in cultured rat hippocampal neurons
per: Patrice G. Bouyer, et al.
Publicat: (2024-10-01)

Gating of cardiac gap junctional channels at acid and alkaline pH
per: Swietach, P, et al.
Publicat: (2005)

CrossTalk opposing view: Physiological CO2 exchange does not normally depend on membrane channels
per: Hulikova, A, et al.
Publicat: (2015)

Modelling intracellular H(+) ion diffusion.
per: Swietach, P, et al.
Publicat: (2003)

Effect of intracellular and extracellular pH on contraction in isolated, mammalian cardiac muscle.
per: Bountra, C, et al.
Publicat: (1989)

Impact of various buffers and weak bases on lysosomal and intracellular pH: Implications for infectivity of SARS‐CoV‐2
per: Jeffrey A. Kraut, et al.
Publicat: (2023-04-01)