Synthesis of a novel bis-amino-modified thymidine monomer for use in DNA triplex stabilisation
A novel thymidine analogue containing both 5-aminopropargyl and 2'-aminoethoxy modifications has been synthesised and incorporated into a triplex-forming oligonucleotide; the combination of the two amino groups on the same nucleoside greatly enhances triplex stability.
| Autori principali: | , , , |
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| Natura: | Journal article |
| Lingua: | English |
| Pubblicazione: |
2000
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