Total synthesis of (−)-himalensine A

The first enantioselective synthesis of (-)-himalensine A has been achieved in 22 steps. The synthesis was enabled by a novel catalytic, enantioselective prototropic shift/furan Diels-Alder (IMDAF) cascade to construct the ACD tricyclic core. A reductive radical cyclization cascade was utilized to b...

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Bibliographic Details
Main Authors: Shi, H, Michaelides, I, Darses, B, Jakubec, P, Nguyen, Q, Paton, R, Dixon, D
Format: Journal article
Language:English
Published: American Chemical Society 2017