Regulation of L-type calcium channel and delayed rectifier potassium channel activity by p21-activated kinase-1 in guinea pig sinoatrial node pacemaker cells.

Phosphorylation of ion channels plays an important role in the regulation of cardiac function, but signaling mechanisms controlling dephosphorylation are not well understood. We have tested the hypothesis that p(21)-activated kinase-1 (Pak1), a serine-threonine protein kinase regulated by Ras-relate...

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Bibliographic Details
Main Authors: Ke, Y, Lei, M, Collins, T, Rakovic, S, Mattick, P, Yamasaki, M, Brodie, MS, Terrar, D, Solaro, R
Format: Journal article
Language:English
Published: 2007