Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza.

BACKGROUND: New prophylactic and therapeutic strategies to combat human infections with highly pathogenic avian influenza (HPAI) H5N1 viruses are needed. We generated neutralizing anti-H5N1 human monoclonal antibodies (mAbs) and tested their efficacy for prophylaxis and therapy in a murine model of...

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Bibliographic Details
Main Authors: Simmons, C, Bernasconi, N, Suguitan, A, Mills, K, Ward, J, Chau, N, Hien, T, Sallusto, F, Ha, D, Farrar, J, Jong, d, Lanzavecchia, A, Subbarao, K
Format: Journal article
Language:English
Published: Public Library of Science 2007