Metabolic perturbations in the pathogenesis of hypertrophic cardiomyopathy

Metabolic perturbations in the pathogenesis of hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy (HCM) has been informative as a genetic model of cardiac hypertrophy. Unexpectedly, analysis of the diverse sarcomeric mutations that typically cause HCM has implicated energetic compromise in pathogenesis. Mutations in a regulatory subunit of AMP-activated protein kinase...

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Bibliographic Details
Main Authors:	Ashrafian, H, Watkins, H
Format:	Journal article
Language:	English
Published:	2005

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