Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals.

Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals.

OBJECTIVE: Recently, it has been shown that a homozygous 32 base-pair deletion in the gene encoding CKR-5, a major coreceptor for HIV-1, leads to resistance to infection with HIV-1. We have investigated whether HIV-seropositive individuals who were heterozygous for the CKR-5 deletion had a different...

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Bibliographic Details
Main Authors: Eugen-Olsen, J, Iversen, A, Garred, P, Koppelhus, U, Pedersen, C, Benfield, T, Sorensen, A, Katzenstein, T, Dickmeiss, E, Gerstoft, J, Skinhøj, P, Svejgaard, A, Nielsen, J, Hofmann, B
Format: Journal article
Language:English
Published: 1997

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