CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease

Parkinson’s disease (PD) affects millions of patients worldwide and is characterized by alpha-synuclein aggregation in dopamine neurons. Molecular tweezers have shown high potential as anti-aggregation agents targeting positively charged residues of proteins undergoing amyloidogenic processes. Here...

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Bibliographic Details
Main Authors: Bengoa-Vergniory, N, Faggiani, E, Ramos-Gonzalez, P, Kirkiz, E, Connor-Robson, N, Brown, L, Siddique, I, Li, Z, Vingill, S, Cioroch, M, Cavaliere, F, Threlfell, S, Roberts, B, Schrader, T, Klärner, F-G, Cragg, S, Gal Bitan, Dehay, B, Matute, C, Bezard, E, Wade-Martins, R
Format: Journal article
Language:English
Published: Springer Nature 2020