CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease

CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease

Show other versions (1)

Parkinson’s disease (PD) affects millions of patients worldwide and is characterized by alpha-synuclein aggregation in dopamine neurons. Molecular tweezers have shown high potential as anti-aggregation agents targeting positively charged residues of proteins undergoing amyloidogenic processes. Here...

Bibliografske podrobnosti
Main Authors:	Bengoa-Vergniory, N, Faggiani, E, Ramos-Gonzalez, P, Kirkiz, E, Connor-Robson, N, Brown, L, Siddique, I, Li, Z, Vingill, S, Cioroch, M, Cavaliere, F, Threlfell, S, Roberts, B, Schrader, T, Klärner, F-G, Cragg, S, Gal Bitan, Dehay, B, Matute, C, Bezard, E, Wade-Martins, R
Format:	Journal article
Jezik:	English
Izdano:	Springer Nature 2020

Podobne knjige/članki

CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease
od: Nora Bengoa-Vergniory, et al.
Izdano: (2020-09-01)

Impairment of macroautophagy in dopamine neurons has opposing effects on parkinsonian pathology and behaviour
od: Hunn, B, et al.
Izdano: (2019)

REST protects dopaminergic neurons from mitochondrial and α-synuclein oligomer pathology in an alpha synuclein overexpressing BAC-transgenic mouse model
od: Ryan, BJ, et al.
Izdano: (2021)

The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice
od: Jing Di, et al.
Izdano: (2021-01-01)

Correction to: The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice
od: Jing Di, et al.
Izdano: (2021-04-01)

Impairment of Macroautophagy in Dopamine Neurons Has Opposing Effects on Parkinsonian Pathology and Behavior
od: Benjamin H.M. Hunn, et al.
Izdano: (2019-10-01)

Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model.
od: Janezic, S, et al.
Izdano: (2013)

Cryptanalysis of the CLR-cryptosystem
od: Micheli, G, et al.
Izdano: (2018)

Transcriptomic insights into the roles of the transcription factors Clr1, Clr2 and Clr4 in lignocellulose degradation of the thermophilic fungal platform Thermothelomyces thermophilus
od: Benedikt Siebecker, et al.
Izdano: (2023-10-01)

Molecular Lysine Tweezers Counteract Aberrant Protein Aggregation
od: Inesa Hadrovic, et al.
Izdano: (2019-10-01)

Inhibition of NK cell cytotoxicity by tubular epithelial cell expression of Clr-b and Clr-f
od: Benjamin Fuhrmann, et al.
Izdano: (2024-01-01)

GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model
od: Roberts, B, et al.
Izdano: (2020)

CLR1 La representación intercultural
od: Issam El Hajjaji
Izdano: (2014-04-01)

DYNAMIC MEMORY ALLOCATION – CLR PROFILER
od: Adrian LUPASC, et al.
Izdano: (2014-06-01)

Inhibition of Mutant αB Crystallin‐Induced Protein Aggregation by a Molecular Tweezer
od: Na Xu, et al.
Izdano: (2017-08-01)

Striatal dopamine transporter function is facilitated by converging biology of α-synuclein and cholesterol
od: Threlfell, S, et al.
Izdano: (2021)

CO-CULTURE OF Α-SYNUCLEIN-TREATED IPSC-DERIVED DOPAMINERGIC NEURONS AND MICROGLIA AS AN IN VITRO MODEL OF PARKINSON’S DISEASE
od: Patricia Villegas-Zafra, et al.
Izdano: (2023-10-01)

Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes
od: Zizheng Li, et al.
Izdano: (2021-09-01)

The Marxian Populism of C.L.R James
od: P.I. Gomes
Izdano: (2024-04-01)

Dopamine signaling in dorsal versus ventral striatum: the dynamic role of cholinergic interneurons.
od: Threlfell, S, et al.
Izdano: (2011)

Dopamine signaling in dorsal versus ventral striatum: The dynamic role of cholinergic interneurons
od: Threlfell, S, et al.
Izdano: (2011)

The Molecular Tweezer CLR01 Inhibits Antibody-Resistant Cell-to-Cell Spread of Human Cytomegalovirus
od: Sina Brenner, et al.
Izdano: (2021-08-01)

Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol
od: Sarah Threlfell, et al.
Izdano: (2021-04-01)

Discovering One’s Own C.L.R. James
od: Anthony P. Maingot
Izdano: (2012-12-01)

Development of chimeric and bifunctional antagonists for CLR/RAMP receptors.
od: Chia Lin Chang, et al.
Izdano: (2019-01-01)

Loss of microRNA-7 regulation leads to α-synuclein accumulation and dopaminergic neuronal loss in vivo
od: McMillan, K, et al.
Izdano: (2017)

Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death
od: Mathieu eBourdenx, et al.
Izdano: (2014-08-01)

Transcription factors FOXA1 and FOXA2 maintain dopaminergic neuronal properties and control feeding behavior in adult mice.
od: Pristerà, A, et al.
Izdano: (2015)

5-HT(1B) receptor regulation of serotonin (5-HT) release by endogenous 5-HT in the substantia nigra.
od: Threlfell, S, et al.
Izdano: (2010)

Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism
od: Dodson, P, et al.
Izdano: (2016)

Dopamine signalling in dorsal versus ventral striatum: the dynamic role of cholinergic interneurons
od: Sarah eThrelfell, et al.
Izdano: (2011-03-01)

Targeting alpha-synuclein as a therapy for Parkinson’s disease
od: Fields, CR, et al.
Izdano: (2019)

Quantitative proteomics reveals CLR interactome in primary human cells
od: Manolis, D, et al.
Izdano: (2024)

C.L.R. James na Mira do Brasil
od: Marcio Farias
Izdano: (2022-12-01)

Clr-f expression regulates kidney immune and metabolic homeostasis
od: Haggag S. Zein, et al.
Izdano: (2022-03-01)

C-Type Lectin Receptor (CLR)–Fc Fusion Proteins As Tools to Screen for Novel CLR/Bacteria Interactions: An Exemplary Study on Preselected Campylobacter jejuni Isolates
od: Sabine Mayer, et al.
Izdano: (2018-02-01)

Nitric oxide donors enhance the frequency dependence of dopamine release in nucleus accumbens.
od: Hartung, H, et al.
Izdano: (2011)

Nitric oxide donors enhance the frequency dependence of dopamine release in nucleus accumbens
od: Hartung, H, et al.
Izdano: (2011)

GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model
od: Bradley M. Roberts, et al.
Izdano: (2020-10-01)

Targeting Alpha-Synuclein as a Therapy for Parkinson’s Disease
od: Carroll Rutherford Fields, et al.
Izdano: (2019-12-01)