A neural code for egocentric spatial maps in the human medial temporal lobe
Spatial navigation and memory rely on neural systems that encode places, distances, and directions in relation to the external world or relative to the navigating organism. Place, grid, and head-direction cells form key units of world-referenced, allocentric cognitive maps, but the neural basis of s...
| Main Authors: | , , , , , , , , , , , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado: |
Cell Press
2021
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| _version_ | 1826310172021096448 |
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| author | Kunz, L Brandt, A Reinacher, PC Staresina, BP Reifenstein, ET Weidemann, CT Herweg, NA Patel, A Tsitsiklis, M Kempter, R Kahana, MJ Schulze-Bonhage, A Jacobs, J |
| author_facet | Kunz, L Brandt, A Reinacher, PC Staresina, BP Reifenstein, ET Weidemann, CT Herweg, NA Patel, A Tsitsiklis, M Kempter, R Kahana, MJ Schulze-Bonhage, A Jacobs, J |
| author_sort | Kunz, L |
| collection | OXFORD |
| description | Spatial navigation and memory rely on neural systems that encode places, distances, and directions in relation to the external world or relative to the navigating organism. Place, grid, and head-direction cells form key units of world-referenced, allocentric cognitive maps, but the neural basis of self-centered, egocentric representations remains poorly understood. Here, we used human single-neuron recordings during virtual spatial navigation tasks to identify neurons providing a neural code for egocentric spatial maps in the human brain. Consistent with previous observations in rodents, these neurons represented egocentric bearings toward reference points positioned throughout the environment. Egocentric bearing cells were abundant in the parahippocampal cortex and supported vectorial representations of egocentric space by also encoding distances toward reference points. Beyond navigation, the observed neurons showed activity increases during spatial and episodic memory recall, suggesting that egocentric bearing cells are not only relevant for navigation but also play a role in human memory. |
| first_indexed | 2024-03-07T07:46:38Z |
| format | Journal article |
| id | oxford-uuid:39a9c736-cdb0-4657-b9dd-bca906e8b7b1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:46:38Z |
| publishDate | 2021 |
| publisher | Cell Press |
| record_format | dspace |
| spelling | oxford-uuid:39a9c736-cdb0-4657-b9dd-bca906e8b7b12023-06-21T14:36:36ZA neural code for egocentric spatial maps in the human medial temporal lobeJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:39a9c736-cdb0-4657-b9dd-bca906e8b7b1EnglishSymplectic ElementsCell Press2021Kunz, LBrandt, AReinacher, PCStaresina, BPReifenstein, ETWeidemann, CTHerweg, NAPatel, ATsitsiklis, MKempter, RKahana, MJSchulze-Bonhage, AJacobs, JSpatial navigation and memory rely on neural systems that encode places, distances, and directions in relation to the external world or relative to the navigating organism. Place, grid, and head-direction cells form key units of world-referenced, allocentric cognitive maps, but the neural basis of self-centered, egocentric representations remains poorly understood. Here, we used human single-neuron recordings during virtual spatial navigation tasks to identify neurons providing a neural code for egocentric spatial maps in the human brain. Consistent with previous observations in rodents, these neurons represented egocentric bearings toward reference points positioned throughout the environment. Egocentric bearing cells were abundant in the parahippocampal cortex and supported vectorial representations of egocentric space by also encoding distances toward reference points. Beyond navigation, the observed neurons showed activity increases during spatial and episodic memory recall, suggesting that egocentric bearing cells are not only relevant for navigation but also play a role in human memory. |
| spellingShingle | Kunz, L Brandt, A Reinacher, PC Staresina, BP Reifenstein, ET Weidemann, CT Herweg, NA Patel, A Tsitsiklis, M Kempter, R Kahana, MJ Schulze-Bonhage, A Jacobs, J A neural code for egocentric spatial maps in the human medial temporal lobe |
| title | A neural code for egocentric spatial maps in the human medial temporal lobe |
| title_full | A neural code for egocentric spatial maps in the human medial temporal lobe |
| title_fullStr | A neural code for egocentric spatial maps in the human medial temporal lobe |
| title_full_unstemmed | A neural code for egocentric spatial maps in the human medial temporal lobe |
| title_short | A neural code for egocentric spatial maps in the human medial temporal lobe |
| title_sort | neural code for egocentric spatial maps in the human medial temporal lobe |
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