METHYL 5-O-TERT-BUTYLDIPHENYLSILYL-2-DEOXY-ALPHA,BETA-D-THREO-PENTOFURANOSIDE AS A DIVERGENT INTERMEDIATE FOR THE SYNTHESIS OF 3'-SUBSTITUTED-2',3'-DIDEOXYNUCLEOSIDES - SYNTHESIS OF 3'-AZIDO-3'-DEOXYTHYMIDINE, 3'-DEOXY-3'-FLUOROTHYMIDINE AND 3'-CYANO-3'-DEOXYTHYMIDINE
The use of methyl 5-0-tert-butyldiphenylsilyl-2-deoxy-α, β -D-threo-pentofuranoside, prepared from D-xylose,as a divergent intermediate for the synthesis of 3'-substituted-2',3'-dideoxynucleosides is illustrated by its conversion into 3'-azido-3'-deoxythymidine, 3'-deox...
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Format: | Journal article |
Language: | English |
Published: |
1988
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