Remodeling of the cardiac pacemaker L-type calcium current and its beta-adrenergic responsiveness in hypertension after neuronal NO synthase gene transfer.

Hypertension is associated with abnormal neurohumoral activation. We tested the hypothesis that beta-adrenergic hyperresponsiveness in the sinoatrial node (SAN) of the spontaneously hypertensive rat occurs at the level of the L-type calcium current because of altered cyclic nucleotide-dependent sign...

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Bibliografische gegevens
Hoofdauteurs: Heaton, D, Lei, M, Li, D, Golding, S, Dawson, T, Mohan, R, Paterson, D
Formaat: Journal article
Taal:English
Gepubliceerd in: 2006