Palladium-catalyzed desulfinative cross-couplings
The Suzuki–Miyaura reaction has undeniably revolutionized the art of synthesis, particularly in the pharmaceutical industry. However, the coupling of 2-pyridine boronic acids has long remained a challenge. In this context, our laboratory has recently reported the use of pyridyl and other heteroaryl...
| Үндсэн зохиолчид: | , |
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| Формат: | Journal article |
| Хэл сонгох: | English |
| Хэвлэсэн: |
Cell Press
2020
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| _version_ | 1826267719685636096 |
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| author | de Gombert, A Willis, MC |
| author_facet | de Gombert, A Willis, MC |
| author_sort | de Gombert, A |
| collection | OXFORD |
| description | The Suzuki–Miyaura reaction has undeniably revolutionized the art of synthesis, particularly in the pharmaceutical industry. However, the coupling of 2-pyridine boronic acids has long remained a challenge. In this context, our laboratory has recently reported the use of pyridyl and other heteroaryl sulfinate salts as efficient alternatives to boron reagents. This new reaction successfully yields industrially relevant building blocks, the synthesis of which would be challenging using classic boron-based nucleophiles. |
| first_indexed | 2024-03-06T20:58:30Z |
| format | Journal article |
| id | oxford-uuid:3a128c20-7488-4a45-a9db-e4eab60aa0da |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:58:30Z |
| publishDate | 2020 |
| publisher | Cell Press |
| record_format | dspace |
| spelling | oxford-uuid:3a128c20-7488-4a45-a9db-e4eab60aa0da2022-03-26T13:59:22ZPalladium-catalyzed desulfinative cross-couplingsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3a128c20-7488-4a45-a9db-e4eab60aa0daEnglishSymplectic ElementsCell Press2020de Gombert, AWillis, MCThe Suzuki–Miyaura reaction has undeniably revolutionized the art of synthesis, particularly in the pharmaceutical industry. However, the coupling of 2-pyridine boronic acids has long remained a challenge. In this context, our laboratory has recently reported the use of pyridyl and other heteroaryl sulfinate salts as efficient alternatives to boron reagents. This new reaction successfully yields industrially relevant building blocks, the synthesis of which would be challenging using classic boron-based nucleophiles. |
| spellingShingle | de Gombert, A Willis, MC Palladium-catalyzed desulfinative cross-couplings |
| title | Palladium-catalyzed desulfinative cross-couplings |
| title_full | Palladium-catalyzed desulfinative cross-couplings |
| title_fullStr | Palladium-catalyzed desulfinative cross-couplings |
| title_full_unstemmed | Palladium-catalyzed desulfinative cross-couplings |
| title_short | Palladium-catalyzed desulfinative cross-couplings |
| title_sort | palladium catalyzed desulfinative cross couplings |
| work_keys_str_mv | AT degomberta palladiumcatalyzeddesulfinativecrosscouplings AT willismc palladiumcatalyzeddesulfinativecrosscouplings |