PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis

PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis

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Studies employing mouse models have identified crypt base and position +4 cells as strong candidates for intestinal epithelial stem cells. Equivalent cell populations are thought to exist in the human intestine; however robust and specific protein markers are lacking. Here, we show that in the human...

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Bibliographic Details
Main Authors: Sakthianandeswaren, A, Christie, M, D'Andreti, C, Tsui, C, Jorissen, R, Li, S, Fleming, N, Gibbs, P, Lipton, L, Malaterre, J, Ramsay, R, Phesse, T, Ernst, M, Jeffery, R, Poulsom, R, Leedham, S, Segditsas, S, Tomlinson, I, Bernhard, O, Simpson, R, Walker, F, Faux, M, Church, N, Catimel, B, Flanagan, D
Format: Journal article
Language:English
Published: 2011

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