A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding.

A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding.

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A rare germline duplication upstream of the bone morphogenetic protein antagonist GREM1 causes a Mendelian-dominant predisposition to colorectal cancer (CRC). The underlying disease mechanism is strong, ectopic GREM1 overexpression in the intestinal epithelium. Here, we confirm that a common GREM1 p...

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Hlavní autoři: Lewis, A, Freeman-Mills, L, de la Calle-Mustienes, E, Giráldez-Pérez, R, Davis, H, Jaeger, E, Becker, M, Hubner, N, Nguyen, L, Zeron-Medina, J, Bond, G, Stunnenberg, H, Carvajal, J, Gomez-Skarmeta, J, Leedham, S, Tomlinson, I
Médium: Journal article
Jazyk:English
Vydáno: 2014

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