Functions of bromodomain-containing proteins and their roles in homeostasis and cancer
Bromodomains (BRDs) are evolutionarily conserved protein–protein interaction modules that are found in a wide range of proteins with diverse catalytic and scaffolding functions and are present in most tissues. BRDs selectively recognize and bind to acetylated Lys residues — particularly in histones...
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| Format: | Journal article |
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Nature Publishing Group
2017
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| _version_ | 1797063393579892736 |
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| author | Fujisawa, T Filippakopoulos, P |
| author_facet | Fujisawa, T Filippakopoulos, P |
| author_sort | Fujisawa, T |
| collection | OXFORD |
| description | Bromodomains (BRDs) are evolutionarily conserved protein–protein interaction modules that are found in a wide range of proteins with diverse catalytic and scaffolding functions and are present in most tissues. BRDs selectively recognize and bind to acetylated Lys residues — particularly in histones — and thereby have important roles in the regulation of gene expression. BRD-containing proteins are frequently dysregulated in cancer, they participate in gene fusions that generate diverse, frequently oncogenic proteins, and many cancer-causing mutations have been mapped to the BRDs themselves. Importantly, BRDs can be targeted by small-molecule inhibitors, which has stimulated many translational research projects that seek to attenuate the aberrant functions of BRD-containing proteins in disease. |
| first_indexed | 2024-03-06T20:59:12Z |
| format | Journal article |
| id | oxford-uuid:3a4e311c-2089-4dfb-a94c-da7c9314e336 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T20:59:12Z |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:3a4e311c-2089-4dfb-a94c-da7c9314e3362022-03-26T14:00:48ZFunctions of bromodomain-containing proteins and their roles in homeostasis and cancerJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3a4e311c-2089-4dfb-a94c-da7c9314e336Symplectic Elements at OxfordNature Publishing Group2017Fujisawa, TFilippakopoulos, PBromodomains (BRDs) are evolutionarily conserved protein–protein interaction modules that are found in a wide range of proteins with diverse catalytic and scaffolding functions and are present in most tissues. BRDs selectively recognize and bind to acetylated Lys residues — particularly in histones — and thereby have important roles in the regulation of gene expression. BRD-containing proteins are frequently dysregulated in cancer, they participate in gene fusions that generate diverse, frequently oncogenic proteins, and many cancer-causing mutations have been mapped to the BRDs themselves. Importantly, BRDs can be targeted by small-molecule inhibitors, which has stimulated many translational research projects that seek to attenuate the aberrant functions of BRD-containing proteins in disease. |
| spellingShingle | Fujisawa, T Filippakopoulos, P Functions of bromodomain-containing proteins and their roles in homeostasis and cancer |
| title | Functions of bromodomain-containing proteins and their roles in homeostasis and cancer |
| title_full | Functions of bromodomain-containing proteins and their roles in homeostasis and cancer |
| title_fullStr | Functions of bromodomain-containing proteins and their roles in homeostasis and cancer |
| title_full_unstemmed | Functions of bromodomain-containing proteins and their roles in homeostasis and cancer |
| title_short | Functions of bromodomain-containing proteins and their roles in homeostasis and cancer |
| title_sort | functions of bromodomain containing proteins and their roles in homeostasis and cancer |
| work_keys_str_mv | AT fujisawat functionsofbromodomaincontainingproteinsandtheirrolesinhomeostasisandcancer AT filippakopoulosp functionsofbromodomaincontainingproteinsandtheirrolesinhomeostasisandcancer |