Direct quantitation of rapid elimination of viral antigen-positive lymphocytes by antiviral CD8(+) T cells in vivo.

Lysis of infected cells by CD8(+) T cells is an important mechanism for the control of virus infections, but remains difficult to quantify in vivo. Here, we study the elimination kinetics of viral antigen-positive lymphocytes by antiviral CD8(+) T cells using flow cytometry and mathematical analysis...

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Bibliographic Details
Main Authors: Barchet, W, Oehen, S, Klenerman, P, Wodarz, D, Bocharov, G, Lloyd, A, Nowak, M, Hengartner, H, Zinkernagel, R, Ehl, S
Format: Journal article
Language:English
Published: 2000