Twisting transition between crystalline and fibrillar phases of aggregated peptides.

Twisting transition between crystalline and fibrillar phases of aggregated peptides.

We study two distinctly ordered condensed phases of polypeptide molecules, amyloid fibrils and amyloidlike microcrystals, and the first-order twisting phase transition between these two states. We derive a single free-energy form which connects both phases. Our model identifies relevant degrees of f...

詳細記述

書誌詳細
主要な著者: Knowles, T, De Simone, A, Fitzpatrick, A, Baldwin, A, Meehan, S, Rajah, L, Vendruscolo, M, Welland, M, Dobson, C, Terentjev, E
フォーマット: Journal article
言語:English
出版事項: 2012
その他の書誌記述
要約:We study two distinctly ordered condensed phases of polypeptide molecules, amyloid fibrils and amyloidlike microcrystals, and the first-order twisting phase transition between these two states. We derive a single free-energy form which connects both phases. Our model identifies relevant degrees of freedom for describing the collective behavior of supramolecular polypeptide structures, reproduces accurately the results from molecular dynamics simulations as well as from experiments, and sheds light on the uniform nature of the dimensions of different peptide fibrils.

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