Development of a Positive-readout Mouse Model of siRNA Pharmacodynamics.

Development of RNAi-based therapeutics has the potential to revolutionize treatment options for a range of human diseases. However, as with gene therapy, a major barrier to progress is the lack of methods to achieve and measure efficient delivery for systemic administration. We have developed a posi...

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Bibliographic Details
Main Authors: Stevenson, M, Carlisle, R, Davies, B, Preece, C, Hammett, M, Liu, W, Fisher, K, Ryan, A, Scrable, H, Seymour, L
Format: Journal article
Language:English
Published: Nature Publishing Group 2013