Development of a Positive-readout Mouse Model of siRNA Pharmacodynamics.
Development of RNAi-based therapeutics has the potential to revolutionize treatment options for a range of human diseases. However, as with gene therapy, a major barrier to progress is the lack of methods to achieve and measure efficient delivery for systemic administration. We have developed a posi...
Main Authors: | Stevenson, M, Carlisle, R, Davies, B, Preece, C, Hammett, M, Liu, W, Fisher, K, Ryan, A, Scrable, H, Seymour, L |
---|---|
Format: | Journal article |
Language: | English |
Published: |
Nature Publishing Group
2013
|
Similar Items
-
Development of a Transgenic Reporter Mouse for Positive-Readout siRNA Pharmacodynamic Analysis
by: Stevenson, M, et al.
Published: (2010) -
Establishment of a positive-readout reporter system for siRNAs
by: Liu, W, et al.
Published: (2009) -
Quantification of siRNA using competitive qPCR.
by: Liu, W, et al.
Published: (2009) -
Delivery of siRNA mediated by histidine-containing reducible polycations.
by: Stevenson, M, et al.
Published: (2008) -
Paclitaxel combined with siRNA targeting HPV16 oncogenes improves cytotoxicity for cervical carcinoma.
by: Liu, W, et al.
Published: (2009)