The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production.

The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production.

NF-ATc1 is a member of a family of genes that encodes the cytoplasmic component of the nuclear factor of activated T cells (NF-AT). In activated T cells, nuclear NF-AT binds to the promoter regions of multiple cytokine genes and induces their transcription. The role of NF-ATc1 was investigated in re...

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Bibliographische Detailangaben
Hauptverfasser: Yoshida, H, Nishina, H, Takimoto, H, Marengère, L, Wakeham, A, Bouchard, D, Kong, Y, Ohteki, T, Shahinian, A, Bachmann, M, Ohashi, P, Penninger, J, Crabtree, G, Mak, T
Format: Journal article
Sprache:English
Veröffentlicht: 1998
Beschreibung
Zusammenfassung:NF-ATc1 is a member of a family of genes that encodes the cytoplasmic component of the nuclear factor of activated T cells (NF-AT). In activated T cells, nuclear NF-AT binds to the promoter regions of multiple cytokine genes and induces their transcription. The role of NF-ATc1 was investigated in recombination activating gene-1 (RAG-1)-deficient blastocyst complementation assays using homozygous NF-ATc1-/- mutant ES cell lines. NF-ATc1-/-/RAG-1-/- chimeric mice showed reduced numbers of thymocytes and impaired proliferation of peripheral lymphocytes, but normal production of IL-2. Induction in vitro of Th2 responses, as demonstrated by a decrease in IL-4 and IL-6 production, was impaired in mutant T cells. These data indicate that NF-ATc1 plays roles in the development of T lymphocytes and in the differentiation of the Th2 response.

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