The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production.
NF-ATc1 is a member of a family of genes that encodes the cytoplasmic component of the nuclear factor of activated T cells (NF-AT). In activated T cells, nuclear NF-AT binds to the promoter regions of multiple cytokine genes and induces their transcription. The role of NF-ATc1 was investigated in re...
| Hlavní autoři: | , , , , , , , , , , , , , |
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| Médium: | Journal article |
| Jazyk: | English |
| Vydáno: |
1998
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| _version_ | 1826267849910386688 |
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| author | Yoshida, H Nishina, H Takimoto, H Marengère, L Wakeham, A Bouchard, D Kong, Y Ohteki, T Shahinian, A Bachmann, M Ohashi, P Penninger, J Crabtree, G Mak, T |
| author_facet | Yoshida, H Nishina, H Takimoto, H Marengère, L Wakeham, A Bouchard, D Kong, Y Ohteki, T Shahinian, A Bachmann, M Ohashi, P Penninger, J Crabtree, G Mak, T |
| author_sort | Yoshida, H |
| collection | OXFORD |
| description | NF-ATc1 is a member of a family of genes that encodes the cytoplasmic component of the nuclear factor of activated T cells (NF-AT). In activated T cells, nuclear NF-AT binds to the promoter regions of multiple cytokine genes and induces their transcription. The role of NF-ATc1 was investigated in recombination activating gene-1 (RAG-1)-deficient blastocyst complementation assays using homozygous NF-ATc1-/- mutant ES cell lines. NF-ATc1-/-/RAG-1-/- chimeric mice showed reduced numbers of thymocytes and impaired proliferation of peripheral lymphocytes, but normal production of IL-2. Induction in vitro of Th2 responses, as demonstrated by a decrease in IL-4 and IL-6 production, was impaired in mutant T cells. These data indicate that NF-ATc1 plays roles in the development of T lymphocytes and in the differentiation of the Th2 response. |
| first_indexed | 2024-03-06T21:00:33Z |
| format | Journal article |
| id | oxford-uuid:3abcf51a-a7ce-4e51-b8d8-de10ab62df64 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:00:33Z |
| publishDate | 1998 |
| record_format | dspace |
| spelling | oxford-uuid:3abcf51a-a7ce-4e51-b8d8-de10ab62df642022-03-26T14:03:27ZThe transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3abcf51a-a7ce-4e51-b8d8-de10ab62df64EnglishSymplectic Elements at Oxford1998Yoshida, HNishina, HTakimoto, HMarengère, LWakeham, ABouchard, DKong, YOhteki, TShahinian, ABachmann, MOhashi, PPenninger, JCrabtree, GMak, TNF-ATc1 is a member of a family of genes that encodes the cytoplasmic component of the nuclear factor of activated T cells (NF-AT). In activated T cells, nuclear NF-AT binds to the promoter regions of multiple cytokine genes and induces their transcription. The role of NF-ATc1 was investigated in recombination activating gene-1 (RAG-1)-deficient blastocyst complementation assays using homozygous NF-ATc1-/- mutant ES cell lines. NF-ATc1-/-/RAG-1-/- chimeric mice showed reduced numbers of thymocytes and impaired proliferation of peripheral lymphocytes, but normal production of IL-2. Induction in vitro of Th2 responses, as demonstrated by a decrease in IL-4 and IL-6 production, was impaired in mutant T cells. These data indicate that NF-ATc1 plays roles in the development of T lymphocytes and in the differentiation of the Th2 response. |
| spellingShingle | Yoshida, H Nishina, H Takimoto, H Marengère, L Wakeham, A Bouchard, D Kong, Y Ohteki, T Shahinian, A Bachmann, M Ohashi, P Penninger, J Crabtree, G Mak, T The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. |
| title | The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. |
| title_full | The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. |
| title_fullStr | The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. |
| title_full_unstemmed | The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. |
| title_short | The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. |
| title_sort | transcription factor nf atc1 regulates lymphocyte proliferation and th2 cytokine production |
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