Single-cell sequencing of iPSC-dopamine neurons reconstructs disease progression and identifies HDAC4 as a regulator of Parkinson cell phenotypes

Single-cell sequencing of iPSC-dopamine neurons reconstructs disease progression and identifies HDAC4 as a regulator of Parkinson cell phenotypes

Induced pluripotent stem cell (iPSC)-derived dopamine neurons provide an opportunity to model Parkinson’s disease (PD), but neuronal cultures are confounded by asynchronous and heterogeneous appearance of disease phenotypes in vitro. Using high-resolution, single-cell transcriptomic analyses of iPSC...

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Detalhes bibliográficos
Principais autores: Lang, C, Campbell, K, Ryan, B, Carling, P, Attar, M, Vowles, J, Perestenko, O, Bowden, R, Baig, F, Kasten, M, Hu, M, Cowley, S, Webber, C, Wade-Martins, R
Formato: Journal article
Publicado em: Elsevier 2018

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