Targeting group II PAKs in cancer and metastasis.

Targeting group II PAKs in cancer and metastasis.

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The p21 activated kinases (PAKs) play an essential role in cell signaling and control a variety of cellular functions including cell motility, survival, angiogenesis and mitosis. PAKs are important regulators in growth factor signaling, cytoskeletal reorganization and growth factor-mediated cell mig...

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Bibliographic Details
Main Authors:	Eswaran, J, Soundararajan, M, Knapp, S
Format:	Journal article
Language:	English
Published:	2009
Subjects:	pharmacology metabolism Crystallography, X-Ray Cytoskeleton Apoptosis Mitosis Animals Gene Expression Regulation, Neoplastic Drug Design Neoplasms Neoplasm Metastasis Antineoplastic Agents Neurons Humans p21-Activated Kinases Cell Transformation, Neoplastic pathology Chemistry, Pharmaceutical methods

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