Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 and Ebola virus interactions.

Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 and Ebola virus interactions.

Niemann-pick type C1 (NPC1) is an endo/lysosomal membrane protein involved in intracellular cholesterol trafficking, and its luminal domain C is an essential endosomal receptor for Ebola and Marburg viruses. We have determined the crystal structure of glycosylated NPC1 luminal domain C and find all...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Zhao, Y, Ren, J, Harlos, K, Stuart, D
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	Wiley 2016

Eitemau Tebyg

Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins
gan: Piyali Saha, et al.
Cyhoeddwyd: (2020-05-01)

The NPC pathway and persistence of intracellular pathogens
gan: Weng, Y
Cyhoeddwyd: (2023)

MemoryRepository for AI NPC
gan: Shijie Zheng, et al.
Cyhoeddwyd: (2024-01-01)

Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies
gan: Zachary A. Bornholdt, et al.
Cyhoeddwyd: (2016-03-01)

An overview of the role of Niemann-pick C1 (NPC1) in viral infections and inhibition of viral infections through NPC1 inhibitor
gan: Irfan Ahmad, et al.
Cyhoeddwyd: (2023-12-01)

LMP-1 and Nasopharyngeal Carcinoma (NPC)
gan: Anggun Indah Budiningrum, et al.
Cyhoeddwyd: (2014-06-01)

Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection
gan: Feiran Lu, et al.
Cyhoeddwyd: (2015-12-01)

AAV9-NPC1 significantly ameliorates Purkinje cell death and behavioral abnormalities in mouse NPC disease
gan: Chang Xie, et al.
Cyhoeddwyd: (2017-03-01)

FTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann-Pick type C mutant fibroblasts
gan: Newton, J, et al.
Cyhoeddwyd: (2017)

Nasopharyngeal carcinoma (NPC) with liver metastasis in pregnancy
gan: Zakaria, Atiqah Farah, et al.
Cyhoeddwyd: (2016)

The role of NPC1L1 in cancer
gan: Renshuai Zhang, et al.
Cyhoeddwyd: (2022-08-01)

New Active-Stacked-NPC Multilevel Converter
gan: Dan Floricau, et al.
Cyhoeddwyd: (2009-10-01)

The NPC Families Mediate BmNPV Entry
gan: Youpeng Fan, et al.
Cyhoeddwyd: (2022-08-01)

The structure of the NPC1L1 N-terminal domain in a closed conformation.
gan: Hyock Joo Kwon, et al.
Cyhoeddwyd: (2011-04-01)

Prognostic significance of high NPC2 expression in gastric cancer
gan: Yunzhuang Yao, et al.
Cyhoeddwyd: (2023-11-01)

Niemann-Pick Disease Type C (NPDC) by Mutation of <i>NPC1</i> and <i>NPC2</i>: Aberrant Lysosomal Cholesterol Trafficking and Oxidative Stress
gan: Dongun Lee, et al.
Cyhoeddwyd: (2023-11-01)

Design and development of neutral-point clamped (NPC) inverter
gan: Shan, Yuqing
Cyhoeddwyd: (2020)

Refinements of the Hermite–Hadamard Inequality in NPC Global Spaces
gan: Conde Cristian
Cyhoeddwyd: (2018-09-01)

Integrated Control and Modulation for Three-Level NPC Rectifiers
gan: Antonio Ventosa-Cutillas, et al.
Cyhoeddwyd: (2019-04-01)

Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid
gan: Leslie A McCauliff, et al.
Cyhoeddwyd: (2019-10-01)

Interaction of functional <it>NPC1 </it>gene Polymorphism with smoking on coronary heart disease
gan: Hui Rutai, et al.
Cyhoeddwyd: (2010-10-01)

Toremifene interacts with and destabilizes the Ebola virus glycoprotein
gan: Zhao, Y, et al.
Cyhoeddwyd: (2016)

Toremifene interacts with and destabilizes the Ebola virus glycoprotein.
gan: Zhao, Y, et al.
Cyhoeddwyd: (2016)

Evaluation of the landscape of pharmacodynamic biomarkers in Niemann-Pick Disease Type C (NPC)
gan: Sydney Stern, et al.
Cyhoeddwyd: (2024-07-01)

Severe neurometabolic phenotype in npc1−/− zebrafish with a C-terminal mutation
gan: Ana Quelle-Regaldie, et al.
Cyhoeddwyd: (2023-03-01)

Nonparametric Combination (NPC): A Framework for Testing Elaborate Theories
gan: Caughey, Devin, et al.
Cyhoeddwyd: (2018)

Nonparametric combination (NPC): a framework for testing elaborate theories
gan: Caughey, D, et al.
Cyhoeddwyd: (2017)

Biomarkers in Nasopharyngeal Carcinoma (NPC): Clinical relevance and prognostic potential
gan: Madhan Krishnan, et al.
Cyhoeddwyd: (2024-09-01)

The Role of NK Cells in EBV Infection and EBV-Associated NPC
gan: Yi Tian Png, et al.
Cyhoeddwyd: (2021-02-01)

The politics of the NPC meme: Reactionary subcultural practice and vernacular theory
gan: Rob Gallagher, et al.
Cyhoeddwyd: (2023-01-01)

Primary treatment results of Nasopharyngeal Carcinoma (NPC) in Yogyakarta, Indonesia.
gan: Maarten A Wildeman, et al.
Cyhoeddwyd: (2013-01-01)

Reovirus infection is regulated by NPC1 and endosomal cholesterol homeostasis.
gan: Paula Ortega-Gonzalez, et al.
Cyhoeddwyd: (2022-03-01)

Genetic variations and treatments that affect the lifespan of the NPC1 mouse
gan: Benny Liu, et al.
Cyhoeddwyd: (2008-03-01)

Components of the LINC and NPC complexes coordinately target and translocate a virus into the nucleus to promote infection.
gan: Chelsey C Spriggs, et al.
Cyhoeddwyd: (2022-09-01)

Structural and biochemical analysis of the Y-shaped Nup84 subcomplex of the NPC
gan: Leksa, Nina Carolina
Cyhoeddwyd: (2012)

NPC photovoltaic grid-connected inverter using proportional-resonant controller
gan: Maswood, Ali Iftekhar, et al.
Cyhoeddwyd: (2015)

Oxidative stress in NPC1 deficient cells: protective effect of allopregnanolone.
gan: Zampieri, S, et al.
Cyhoeddwyd: (2009)

The role of NPC2 gene in glioma was investigated based on bioinformatics analysis
gan: Guangwei Zheng, et al.
Cyhoeddwyd: (2024-08-01)

NPC1 links cholesterol trafficking to microglial morphology via the gastrosome
gan: Joanna Zareba, et al.
Cyhoeddwyd: (2024-10-01)

Backstepping Control of NPC Multilevel Converter Interfacing AC and DC Microgrids
gan: J. Dionísio Barros, et al.
Cyhoeddwyd: (2023-07-01)