Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 and Ebola virus interactions.

Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 and Ebola virus interactions.

Niemann-pick type C1 (NPC1) is an endo/lysosomal membrane protein involved in intracellular cholesterol trafficking, and its luminal domain C is an essential endosomal receptor for Ebola and Marburg viruses. We have determined the crystal structure of glycosylated NPC1 luminal domain C and find all...

Полное описание

Библиографические подробности
Главные авторы:	Zhao, Y, Ren, J, Harlos, K, Stuart, D
Формат:	Journal article
Язык:	English
Опубликовано:	Wiley 2016

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