A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

A major challenge of genome-wide association studies (GWAS) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulatory...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Ramdas, S, Judd, J, Graham, SE, Chen, Z, Walters, R, Millwood, I, Lin, K
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	Cell Press 2022

समान संसाधन

The power of genetic diversity in genome-wide association studies of lipids
द्वारा: Graham, SE, और अन्य
प्रकाशित: (2021)

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
द्वारा: Kanoni, S, और अन्य
प्रकाशित: (2022)

Interpreting noncoding genetic variation in complex traits and human disease
द्वारा: Kellis, Manolis, और अन्य
प्रकाशित: (2014)

The genetic architecture of depression in individuals of East Asian ancestry: a genome-wide association study
द्वारा: Giannakopoulou, O, और अन्य
प्रकाशित: (2021)

Understanding the genetic complexity of puberty timing across the allele frequency spectrum
द्वारा: Kentistou, KA, और अन्य
प्रकाशित: (2023)

The role of noncoding RNAs in cancer lipid metabolism
द्वारा: Ye Wang, और अन्य
प्रकाशित: (2022-11-01)

The genetic signatures of noncoding RNAs.
द्वारा: John S Mattick
प्रकाशित: (2009-04-01)

A Role for Noncoding Variation in Schizophrenia
द्वारा: Panos Roussos, और अन्य
प्रकाशित: (2014-11-01)

Natural genetic variation as a tool in understanding the role of CETP in lipid levels and disease
द्वारा: S. Matthijs Boekholdt, और अन्य
प्रकाशित: (2003-06-01)

Molecular Crosstalking among Noncoding RNAs: A New Network Layer of Genome Regulation in Cancer
द्वारा: Marco Ragusa, और अन्य
प्रकाशित: (2017-01-01)

Genetic Variation Bias toward Noncoding Regions and Secreted Proteins in the Rice Blast Fungus Magnaporthe oryzae
द्वारा: Zhenhui Zhong, और अन्य
प्रकाशित: (2020-06-01)

Genome regulation by long noncoding RNAs
द्वारा: Engreitz, Jesse M. (Jesse Michael)
प्रकाशित: (2016)

The transferability of lipid loci across African, Asian and European cohorts
द्वारा: Kuchenbaecker, K, और अन्य
प्रकाशित: (2019)

NONCODING CHLOROPLAST DNA VARIATION IN MEXICAN PINES
द्वारा: Delarosa, J, और अन्य
प्रकाशित: (1995)

The role of noncoding genetic variants in cardiomyopathy
द्वारा: Myo Htet, और अन्य
प्रकाशित: (2023-05-01)

Investigation of inherited noncoding genetic variation impacting the pharmacogenomics of childhood acute lymphoblastic leukemia treatment
द्वारा: Kashi Raj Bhattarai, और अन्य
प्रकाशित: (2024-05-01)

Whole-genome sequencing for an enhanced understanding of genetic variation among South Africans
द्वारा: Ananyo Choudhury, और अन्य
प्रकाशित: (2017-12-01)

The coding and noncoding architecture of the Caulobacter crescentus genome.
द्वारा: Jared M Schrader, और अन्य
प्रकाशित: (2014-07-01)

Realizing the significance of noncoding functionality in clinical genomics
द्वारा: Brian S. Gloss, और अन्य
प्रकाशित: (2018-08-01)

Selective Constraint on Noncoding Regions of Hominid Genomes.
प्रकाशित: (2005-12-01)

Selective constraint on noncoding regions of hominid genomes.
द्वारा: Eliot C Bush, और अन्य
प्रकाशित: (2005-12-01)

The roles and mechanisms of coding and noncoding RNA variations in cancer
द्वारा: Sang Yean Kim, और अन्य
प्रकाशित: (2024-09-01)

The inflated mitochondrial genomes of siphonous green algae reflect processes driving expansion of noncoding DNA and proliferation of introns
द्वारा: Sonja I. Repetti, और अन्य
प्रकाशित: (2020-01-01)

Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors
द्वारा: Bakker, MK, और अन्य
प्रकाशित: (2020)

Genetic risk, incident gastric cancer, and healthy lifestyle: a meta-analysis of genome-wide association studies and prospective cohort study
द्वारा: Jin, G, और अन्य
प्रकाशित: (2020)

A large-scale genome-wide association analysis of lung function in the Chinese population identifies novel loci and highlights shared genetic etiology with obesity
द्वारा: Zhu, Z, और अन्य
प्रकाशित: (2021)

Progress in understanding the relationship between long noncoding RNA and endometriosis
द्वारा: Wenying Yan, और अन्य
प्रकाशित: (2020-01-01)

Genetic variations in plasma lipid content in mice
द्वारा: Richard S. Yamamoto, और अन्य
प्रकाशित: (1963-10-01)

Liver regulatory mechanisms of noncoding variants at lipid and metabolic trait loci
द्वारा: Gautam K. Pandey, और अन्य
प्रकाशित: (2024-04-01)

Stroke genetics informs drug discovery and risk prediction across ancestries
द्वारा: Mishra, A, और अन्य
प्रकाशित: (2022)

Quantitative Trait Loci Identify Functional Noncoding Variation in Cancer.
द्वारा: Holger Heyn
प्रकाशित: (2016-03-01)

Noncoding RNA, antigenic variation, and the virulence genes of <it>Plasmodium falciparum</it>
द्वारा: Bright A Taylor, और अन्य
प्रकाशित: (2011-07-01)

The mechanism and function of pervasive noncoding transcription in the mammalian genome
द्वारा: Wu, Xuebing, Ph. D. Massachusetts Institute of Technology
प्रकाशित: (2015)

High-resolution interrogation of functional elements in the noncoding genome
द्वारा: Fontanillas, P., और अन्य
प्रकाशित: (2017)

Genome-wide analysis of long noncoding RNA stability.
द्वारा: Clark, M, और अन्य
प्रकाशित: (2012)

Long noncoding RNA study: Genome-wide approaches
द्वारा: Shuang Tao, और अन्य
प्रकाशित: (2023-11-01)

Genome-wide discovery of structured noncoding RNAs in bacteria
द्वारा: Shira Stav, और अन्य
प्रकाशित: (2019-03-01)

P427: Beyond genomics: Using RNA-seq in filter cards to unlock the clinical relevance of noncoding variation in splicing
द्वारा: Ruslan Al-Ali, और अन्य
प्रकाशित: (2023-01-01)

The regulator of regulators: Understanding the mechanisms behind long noncoding RNA dysregulation
द्वारा: Zhen Yang
प्रकाशित: (2024-03-01)

Current advancements and future perspectives of long noncoding RNAs in lipid metabolism and signaling
द्वारा: Jiufei Duan, और अन्य
प्रकाशित: (2023-06-01)