Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells.

Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells.

OBJECTIVE: Endothelial dysfunction in diabetes is characterized by decreased nitric oxide (NO) bioactivity and increased superoxide (SO) production. Reduced levels of tetrahydrobiopterin (BH4), an essential cofactor of endothelial NO synthase (eNOS), appear to be associated with eNOS enzymatic unco...

תיאור מלא

מידע ביבליוגרפי
Main Authors:	Cai, S, Khoo, J, Channon, K
פורמט:	Journal article
שפה:	English
יצא לאור:	2005

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Neuronal and endothelial nitric oxide synthase gene knockout mice
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יצא לאור: (1999-11-01)

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יצא לאור: (2011)

Endothelial nitric oxide synthase and heart rate.
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יצא לאור: (2002)

Role of nitric oxide and endothelial NO synthase in carcinogenesis
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Targeting and translocation of endothelial nitric oxide synthase
מאת: T. Michel
יצא לאור: (1999-11-01)

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Regulation of endothelial nitric oxide synthase gene expression by oxidized linoleic acid
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Prevention of hypoxia-induced pulmonary hypertension and vascular remodelling by targeting endothelial tetrahydrobiopterin-dependent nitric oxide synthase regulation
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Relationship between the G894T polymorphism (Glu298Asp variant) in endothelial nitric oxide synthase and nitric oxide-mediated endothelial function in human atherosclerosis.
מאת: Guzik, T, et al.
יצא לאור: (2001)

Endothelial Nitric Oxide Synthase in the Perivascular Adipose Tissue
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יצא לאור: (2022-07-01)

Gene transfer of neuronal nitric oxide synthase into intracardiac Ganglia reverses vagal impairment in hypertensive rats.
מאת: Heaton, D, et al.
יצא לאור: (2007)

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יצא לאור: (2021-01-01)

Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling.
מאת: Crabtree, M, et al.
יצא לאור: (2013)

High glutathionylation of placental endothelial nitric oxide synthase in preeclampsia
מאת: Paul Guerby, et al.
יצא לאור: (2019-04-01)

Tetrahydrobiopterin deficiency uncouples nitric oxide synthase and causes pulmonary hypertension
מאת: Khoo, J, et al.
יצא לאור: (2004)

Nitric oxide synthase in atherosclerosis and vascular injury: insights from experimental gene therapy.
מאת: Channon, K, et al.
יצא לאור: (2000)

POLYMORPHISMS OF ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE AS PREDICTORS OF WOLFF-PARKINSON-WHITE SYNDROME
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יצא לאור: (2017-11-01)

Is there a relationship between endothelial nitric oxide synthase gene polymorphisms and ankylosing spondylitis?
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Endothelial Nitric Oxide Synthase Gene T-786C Polymorphism in Renal Transplant Recipients
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Relationships between vascular/plasma biopterins and endothelial nitric oxide synthase coupling, endothelial function and inflammation, in human atherosclerosis
מאת: Antoniades, C, et al.
יצא לאור: (2008)

Role of oxidative stress in the dysfunction of the placental endothelial nitric oxide synthase in preeclampsia
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