Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells.

Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells.

OBJECTIVE: Endothelial dysfunction in diabetes is characterized by decreased nitric oxide (NO) bioactivity and increased superoxide (SO) production. Reduced levels of tetrahydrobiopterin (BH4), an essential cofactor of endothelial NO synthase (eNOS), appear to be associated with eNOS enzymatic unco...

書誌詳細
主要な著者:	Cai, S, Khoo, J, Channon, K
フォーマット:	Journal article
言語:	English
出版事項:	2005

類似資料

Adenovirus-mediated GTP cyclohydrolase I gene delivery augments tetrahydrobiopterin and restores nitric oxide synthase function in hyperglycaemic human aortic endothelial cells
著者:: Cai, S, 等
出版事項: (2004)

Adenovirus-mediated GTP cyclohydrolase I gene delivery augments tetrahydrobiopterin and restores nitric oxide synthase function in hyperglycaemic human aortic endothelial cells
著者:: Cai, S, 等
出版事項: (2004)

Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation.
著者:: Cai, S, 等
出版事項: (2005)

GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: effects on nitric oxide synthase activity, protein levels and dimerisation.
著者:: Cai, S, 等
出版事項: (2002)

Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease.
著者:: Channon, K
出版事項: (2004)

Reduced levels of tetrahydrobiopterin in diabetic mouse model: Effects on endothelial function and nitric oxide (NO) synthase dimerisation
著者:: Cai, S, 等
出版事項: (2004)

Regulation of endothelial nitric oxide synthase (eNOS) by tetrahydrobiopterin in vascular disease
著者:: Alp, N, 等
出版事項: (2004)

Dihydrofolate reductase is required to maintain endothelial nitric oxide synthase coupling in vivo: Insights from methotrexate-treated BH4 deficient and GTPCH overexpressing mice
著者:: Crabtree, M, 等
出版事項: (2010)

Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease.
著者:: Alp, N, 等
出版事項: (2004)

Endothelial tetrahydrobiopterin deficiency accelerates atherosclerotic progression by nitric oxide synthase uncoupling
著者:: Khoo, J, 等
出版事項: (2005)

P683The role of nitric oxide synthase (NOS) and its essential cofactor tetrahydrobiopterin (BH4) in diabetic cardiomyopathy.
著者:: Duglan, D, 等
出版事項: (2014)

The role of nitric oxide synthase (nos) and the cofactor tetrahydrobiopterin (bh4) in diabetic cardiomyopathy
著者:: Duglan, D
出版事項: (2016)

Neuronal nitric oxide synthase gene transfer promotes cardiac vagal gain of function.
著者:: Mohan, R, 等
出版事項: (2002)

Functional assessment of the endothelial nitric oxide synthase Glu298Asp polymorphism
著者:: McDonald, D, 等
出版事項: (2002)

Tetrahydrobiopterin and nitric oxide synthase recouplers
著者:: Channon, KM
出版事項: (2020)

Neuronal and endothelial nitric oxide synthase gene knockout mice
著者:: P.L. Huang
出版事項: (1999-11-01)

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency.
著者:: Crabtree, M, 等
出版事項: (2011)

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency
著者:: Crabtree, M, 等
出版事項: (2011)

Endothelial nitric oxide synthase and heart rate.
著者:: Herring, N, 等
出版事項: (2002)

Role of nitric oxide and endothelial NO synthase in carcinogenesis
著者:: V. P. Deryagina, 等
出版事項: (2021-07-01)

Targeting and translocation of endothelial nitric oxide synthase
著者:: T. Michel
出版事項: (1999-11-01)

Role of Polymorphisms of Inducible Nitric Oxide Synthase and Endothelial Nitric Oxide Synthase in Idiopathic Environmental Intolerances
著者:: Chiara De Luca, 等
出版事項: (2015-01-01)

Functional comparison of the endothelial nitric oxide synthase Glu298Asp polymorphic variants in human endothelial cells.
著者:: McDonald, D, 等
出版事項: (2004)

Regulation of endothelial nitric oxide synthase gene expression by oxidized linoleic acid
著者:: Santhini Ramasamy, 等
出版事項: (1998-02-01)

Tetrahydrobiopterin Prevents Lung Ischemia/reperfusion-Induced Uncoupling of Endothelial Nitric Oxide Synthase
著者:: Juni, R, 等
出版事項: (2012)

Prevention of hypoxia-induced pulmonary hypertension and vascular remodelling by targeting endothelial tetrahydrobiopterin-dependent nitric oxide synthase regulation
著者:: Khoo, J, 等
出版事項: (2005)

Relationship between the G894T polymorphism (Glu298Asp variant) in endothelial nitric oxide synthase and nitric oxide-mediated endothelial function in human atherosclerosis.
著者:: Guzik, T, 等
出版事項: (2001)

Endothelial Nitric Oxide Synthase in the Perivascular Adipose Tissue
著者:: Andy W. C. Man, 等
出版事項: (2022-07-01)

Gene transfer of neuronal nitric oxide synthase into intracardiac Ganglia reverses vagal impairment in hypertensive rats.
著者:: Heaton, D, 等
出版事項: (2007)

Evaluation of Endothelial Nitric Oxide Synthase and Nitric Oxide Levels in Preeclamptic and Normotensive Pregnant Women
著者:: Rajeev Gandham, 等
出版事項: (2021-01-01)

Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling.
著者:: Crabtree, M, 等
出版事項: (2013)

High glutathionylation of placental endothelial nitric oxide synthase in preeclampsia
著者:: Paul Guerby, 等
出版事項: (2019-04-01)

Tetrahydrobiopterin deficiency uncouples nitric oxide synthase and causes pulmonary hypertension
著者:: Khoo, J, 等
出版事項: (2004)

Nitric oxide synthase in atherosclerosis and vascular injury: insights from experimental gene therapy.
著者:: Channon, K, 等
出版事項: (2000)

POLYMORPHISMS OF ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE AS PREDICTORS OF WOLFF-PARKINSON-WHITE SYNDROME
著者:: G. V. Matyushin, 等
出版事項: (2017-11-01)

Is there a relationship between endothelial nitric oxide synthase gene polymorphisms and ankylosing spondylitis?
著者:: Ismail Sari, 等

Is there a relationship between endothelial nitric oxide synthase gene polymorphisms and ankylosing spondylitis?
著者:: Ismail Sari, 等
出版事項: (2013-01-01)

Endothelial Nitric Oxide Synthase Gene T-786C Polymorphism in Renal Transplant Recipients
著者:: N Azarpira, 等
出版事項: (2011-04-01)

Relationships between vascular/plasma biopterins and endothelial nitric oxide synthase coupling, endothelial function and inflammation, in human atherosclerosis
著者:: Antoniades, C, 等
出版事項: (2008)

Role of oxidative stress in the dysfunction of the placental endothelial nitric oxide synthase in preeclampsia
著者:: Paul Guerby, 等
出版事項: (2021-04-01)