DOCK8 is critical for the survival and function of NKT cells.

Patients with the dedicator of cytokinesis 8 (DOCK8) immunodeficiency syndrome suffer from recurrent viral and bacterial infections, hyper-immunoglobulin E levels, eczema, and greater susceptibility to cancer. Because natural killer T (NKT) cells have been implicated in these diseases, we asked if t...

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Bibliographic Details
Main Authors: Crawford, G, Enders, A, Gileadi, U, Stankovic, S, Zhang, Q, Lambe, T, Crockford, T, Lockstone, H, Freeman, A, Arkwright, P, Smart, J, Ma, C, Tangye, S, Goodnow, C, Cerundolo, V, Godfrey, D, Su, H, Randall, K, Cornall, R
Format: Journal article
Language:English
Published: 2013