DOCK8 is critical for the survival and function of NKT cells.
Patients with the dedicator of cytokinesis 8 (DOCK8) immunodeficiency syndrome suffer from recurrent viral and bacterial infections, hyper-immunoglobulin E levels, eczema, and greater susceptibility to cancer. Because natural killer T (NKT) cells have been implicated in these diseases, we asked if t...
Main Authors: | Crawford, G, Enders, A, Gileadi, U, Stankovic, S, Zhang, Q, Lambe, T, Crockford, T, Lockstone, H, Freeman, A, Arkwright, P, Smart, J, Ma, C, Tangye, S, Goodnow, C, Cerundolo, V, Godfrey, D, Su, H, Randall, K, Cornall, R |
---|---|
Format: | Journal article |
Language: | English |
Published: |
2013
|
Similar Items
-
The role of the novel guanine exchange factor, dedicator of cytokinesis 8 (DOCK8), in T cell survival and maintenance of CD8(+) T cell memory
by: Crawford, G, et al.
Published: (2012) -
The essential role of DOCK8 in humoral immunity.
by: Randall, K, et al.
Published: (2010) -
DOCK8 is essential for T-cell survival and the maintenance of CD8+ T-cell memory.
by: Lambe, T, et al.
Published: (2011) -
DOCK8 is essential for T-cell survival and the maintenance of CD8 + T-cell memory
by: Lambe, T, et al.
Published: (2011) -
DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice.
by: Randall, K, et al.
Published: (2011)