Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation.

Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation.

Mutations in the human methyl-CpG-binding protein gene MECP2 cause the neurological disorder Rett syndrome and some cases of X-linked mental retardation (XLMR). We report that MeCP2 interacts with ATRX, a SWI2/SNF2 DNA helicase/ATPase that is mutated in ATRX syndrome (alpha-thalassemia/mental retard...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Nan, X, Hou, J, Maclean, A, Nasir, J, Lafuente, M, Shu, X, Kriaucionis, S, Bird, A
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	2007

समान संसाधन

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The chromatin remodeller ATRX facilitates diverse nuclear processes, in a stochastic manner, in both heterochromatin and euchromatin
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