With No Lysine Kinase 3 (WNK3); A Target Enabling Package

With No Lysine Kinase 3 (WNK3); A Target Enabling Package

A description of the materials and methods is included within the TEP datasheet. Kinases WNK1-4 regulate cation-chloride cotransporters via phosphorylation of SPAK and OSR1 and thereby control salt homeostasis, cell volume and blood pressure. Gain of function mutations in WNK kinases are found in Go...

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Bibliografiske detaljer
Hovedforfatter:	Bullock, A
Andre forfattere:	Pinkas, D
Format:	Dataset
Udgivet:	University of Oxford 2018
Fag:	Structural Genomics Chemical Biology Drug Discovery

Lignende værker

With no lysine kinase 3 (WNK3); A Target Enabling Package
af: Pinkas, D
Udgivet: (2018)

With No Lysine Kinase 3 (WNK3); A Target Enabling Package
af: Pinkas, D
Udgivet: (2018)

LIM Domain Kinase 1 (LIMK1), Human Kinase Domain; A Target Enabling Package
af: Bullock, A
Udgivet: (2018)

Lysine Demethylase JMJD1B (KDM3B); A Target Enabling Package
af: Brennan, P
Udgivet: (2018)

Lysine Demethylase JMJD1B (KDM3B); A Target Enabling Package
af: Brennan, P
Udgivet: (2018)

Lysine Demethylase JMJD1B (KDM3B); A Target Enabling Package
af: Savitsky, P
Udgivet: (2018)

Lysine Demethylase JMJD2D (KDM4D); A Targeting Enabling Package
af: Brennan, P
Udgivet: (2018)

Lysine Demethylase JMJD2D (KDM4D); A Targeting Enabling Package
af: Savitsky, P
Udgivet: (2018)

Lysine Demethylase JMJD2D (KDM4D); A Targeting Enabling Package
af: Brennan, P
Udgivet: (2018)

Cyclin-dependent kinase 12 (CDK12), human kinase domain; a Target Enabling Package
af: Dixon-Clarke, S
Udgivet: (2018)

Cyclin-Dependent Kinase 12 (CDK12), human kinase domain; A Target Enabling Package
Udgivet: (2018)

LIM domain kinase 1 (LIMK1), human kinase domain; A Target Enabling Package
af: Mathea, S
Udgivet: (2018)

Cyclin-Dependent Kinase 12 (CDK12), Human Kinase Domain; A Target Enabling Package
Udgivet: (2018)

LIM Domain Kinase 1 (LIMK1), human kinase domain; A Target Enabling Package
af: Mathea, S
Udgivet: (2018)

Human RECQL5 Helicase; A Target Enabling Package
af: Gileadi, O
Udgivet: (2018)

Human RECQL5 Helicase; A Target Enabling Package
af: Newman, J
Udgivet: (2018)

Human RECQL5 Helicase; A Target Enabling Package
af: Newman, J
Udgivet: (2018)

Pleckstrin Homology Domain Interacting Protein (PHIP); A Target Enabling Package
af: Cox, O
Udgivet: (2018)

Human alpha-aminoadipic semialdehyde synthase (AASS); A Target Enabling Package
Udgivet: (2018)

Pleckstrin Homology Domain Interacting Protein (PHIP); A Target Enabling Package
af: Cox, O
Udgivet: (2018)

Pleckstrin Homology Domain Interacting Protein (PHIP); A Target Enabling Package
af: Brennan, P
Udgivet: (2018)

Human alpha-aminoadipic semialdehyde synthase (AASS); A Target Enabling Package
af: Kopec, J
Udgivet: (2018)

Human alpha-aminoadipic semialdehyde synthase (AASS); A Target Enabling Package
af: Yue, W
Udgivet: (2018)

Dolichyl-Phosphate Alpha-N-Acetyl Glucosaminyl Transferase (DPAGT1); A Target Enabling Package
af: Chu, A
Udgivet: (2018)

Dolichyl-Phosphate Alpha-N-Acetyl Glucosaminyl Transferase (DPAGT1); A Target Enabling Package
af: Carpenter, E
Udgivet: (2018)

Dolichyl-Phosphate Alpha-N-Acetyl Glucosaminyl Transferase (DPAGT1); A Target Enabling Package
af: Dong, Y
Udgivet: (2018)

Human DNA Cross-Link Repair 1A (DCLRE1A, SNM1A); A Target Enabling Package
af: Newman, J
Udgivet: (2018)

Human DNA Cross-Link Repair 1A (DCLRE1A, SNM1A); A Target Enabling Package
af: Gileadi, O
Udgivet: (2018)

Human DNA Cross-Link Repair 1A (DCLRE1A, SNM1A); A Target Enabling Package
af: Newman, J
Udgivet: (2018)

Inhibition of KDM4D and stabilisation of the PHF8 plant homeodomain’s transient structural states using antibodies
af: Wolfreys, F
Udgivet: (2017)

Zebrafish WNK lysine deficient protein kinase 1 (wnk1) affects angiogenesis associated with VEGF signaling.
af: Ju-Geng Lai, et al.
Udgivet: (2014-01-01)

Application of Fragment-Based Drug Discovery to Versatile Targets
af: Qingxin Li
Udgivet: (2020-08-01)

Analysis of multiple compound–protein interactions reveals novel bioactive molecules
af: Hiroaki Yabuuchi, et al.
Udgivet: (2011-03-01)

Connecting genetics and gene expression data for target prioritisation and drug repositioning
af: Enrico Ferrero, et al.
Udgivet: (2018-05-01)

Targeting the ubiquitin system by fragment-based drug discovery
af: Cassandra Kennedy, et al.
Udgivet: (2022-09-01)

Advances in omics-based methods to identify novel targets for malaria and other parasitic protozoan infections
af: Annie N. Cowell, et al.
Udgivet: (2019-10-01)

Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation.
af: Schumacher, F, et al.
Udgivet: (2014)

Too weak for biophysics: Prioritising and progressing fragment hits from X-ray crystallographic screening.
af: Dubianok, Y
Udgivet: (2021)

Structural basis for pharmacological modulation of the TRPC6 channel
af: Yonghong Bai, et al.
Udgivet: (2020-03-01)

Knowledge graph analytics platform with LINCS and IDG for Parkinson's disease target illumination
af: Jeremy J. Yang, et al.
Udgivet: (2022-01-01)