Investigation of osteoclastogenic signalling of the RANKL substitute LIGHT

LIGHT (TNFSF14) is a member of the TNF superfamily and is known to substitute for RANKL to induce osteoclast differentiation. LIGHT binds HVEM and LTβR, but it is not known whether these receptors play a role in osteoclast formation or whether LIGHT acts via RANKL signalling pathways. We found that...

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Bibliographic Details
Main Authors: Hemingway, F, Kashima, T, Knowles, H, Athanasou, N
Format: Journal article
Language:English
Published: 2013