Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome.

Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome.

Type II SH2 domain-containing inositol 5-phosphatase (INPPL1, or SHIP2) plays an important role in the control of insulin sensitivity. INPPL1 mutations affecting gene function have been found in rat models of type 2 diabetes and hypertension and in type 2 diabetic patients. We investigated the influ...

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Bibliographic Details
Main Authors: Kaisaki, P, Delépine, M, Woon, P, Sebag-Montefiore, L, Wilder, S, Menzel, S, Vionnet, N, Marion, E, Riveline, J, Charpentier, G, Schurmans, S, Levy, J, Lathrop, M, Farrall, M, Gauguier, D
Format: Journal article
Language:English
Published: 2004

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