Long chain CoA esters as competitive antagonists of phosphatidylinositol 4,5-bisphosphate activation in Kir channels.
Long chain fatty acid esters of coenzyme A (LC-CoA) are potent activators of ATP-sensitive (K(ATP)) channels, and elevated levels have been implicated in the pathophysiology of type 2 diabetes. This stimulatory effect is thought to involve a mechanism similar to phosphatidylinositol 4,5-bisphosphate...
Հիմնական հեղինակներ: | Rapedius, M, Soom, M, Shumilina, E, Schulze, D, Schönherr, R, Kirsch, C, Lang, F, Tucker, S, Baukrowitz, T |
---|---|
Ձևաչափ: | Journal article |
Լեզու: | English |
Հրապարակվել է: |
2005
|
Նմանատիպ նյութեր
-
Structure and Lateral Organization of Phosphatidylinositol 4,5-bisphosphate
: Luís Borges-Araújo, և այլն
Հրապարակվել է: (2020-08-01) -
Simulation-based prediction of phosphatidylinositol 4,5-bisphosphate binding to an ion channel.
: Schmidt, MR, և այլն
Հրապարակվել է: (2013) -
Conformational rearrangements during PIP2 gating in Kir channels
: Rapedius, M, և այլն
Հրապարակվել է: (2007) -
Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate
: Harlan, John E., և այլն
Հրապարակվել է: (2012) -
Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis
: Alexander M Walter, և այլն
Հրապարակվել է: (2017-10-01)