Long chain CoA esters as competitive antagonists of phosphatidylinositol 4,5-bisphosphate activation in Kir channels.

Long chain CoA esters as competitive antagonists of phosphatidylinositol 4,5-bisphosphate activation in Kir channels.

Long chain fatty acid esters of coenzyme A (LC-CoA) are potent activators of ATP-sensitive (K(ATP)) channels, and elevated levels have been implicated in the pathophysiology of type 2 diabetes. This stimulatory effect is thought to involve a mechanism similar to phosphatidylinositol 4,5-bisphosphate...

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Detalhes bibliográficos
Main Authors:	Rapedius, M, Soom, M, Shumilina, E, Schulze, D, Schönherr, R, Kirsch, C, Lang, F, Tucker, S, Baukrowitz, T
Formato:	Journal article
Idioma:	English
Publicado em:	2005

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