The structure of Pneumocystis carinii dihydrofolate reductase to 1.9 A resolution.

The structure of Pneumocystis carinii dihydrofolate reductase to 1.9 A resolution.

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BACKGROUND: The fungal pathogen Pneumocystis carinii causes a pneumonia which is an opportunistic infection of AIDS patients. Current therapy includes the dihydrofolate reductase (DHFR) inhibitor trimethoprim which is selective but only a relatively weak inhibitor of the enzyme for P. carinii. Deter...

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Dades bibliogràfiques
Autors principals:	Champness, J, Achari, A, Ballantine, S, Bryant, P, Delves, C, Stammers, D
Format:	Journal article
Idioma:	English
Publicat:	1994

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