Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors.

The structure of unliganded HIV-1 reverse transcriptase has been determined at 2.35 A resolution and refined to an R-factor of 0.219 (for all data) with good stereochemistry. The unliganded structure was produced by soaking out a weak binding non-nucleoside inhibitor, HEPT, from pregrown crystals. C...

Повний опис

Бібліографічні деталі
Автори: Esnouf, R, Ren, J, Ross, C, Jones, E, Stammers, D, Stuart, D
Формат: Journal article
Мова:English
Опубліковано: 1995