cGAS facilitates sensing of extracellular cyclic dinucleotides to activate innate immunity

Cyclic dinucleotides (CDNs) are important second messenger molecules in prokaryotes and eukaryotes. Within host cells, cytosolic CDNs are detected by STING and alert the host by activating innate immunity characterized by type I interferon (IFN) responses. Extracellular bacteria and dying cells can...

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Bibliographic Details
Main Authors:	Liu, H, Moura-Alves, P, Pei, G, Mollenkopf, H, Hurwitz, R, Wu, X, Wang, F, Liu, S, Ma, M, Fei, Y, Zhu, C, Koehler, A, Oberbeck-Mueller, D, Hahnke, K, Klemm, M, Guhlich-Bornhof, U, Ge, B, Tuukkanen, A, Kolbe, M, Dorhoi, A, Kaufmann, S
Format:	Journal article
Language:	English
Published:	EMBO Press 2019

cGAS facilitates sensing of extracellular cyclic dinucleotides to activate innate immunity

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