Mutations at amino acid position 315 of the katG gene are associated with high-level resistance to isoniazid, other drug resistance, and successful transmission of Mycobacterium tuberculosis in the Netherlands.

The prevalence of mutations at amino acid (aa) position 315 in the katG gene of isoniazid (INH)-resistant Mycobacterium tuberculosis isolates in The Netherlands and the mutation's association with the level of INH resistance, multidrug resistance, and transmission were determined. Of 4288 M. tu...

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Bibliographic Details
Main Authors: van Soolingen, D, de Haas, P, Van Doorn, H, Kuijper, E, Rinder, H, Borgdorff, M
Format: Journal article
Language:English
Published: 2000