Trapping of palindromic ligands within native transthyretin prevents amyloid formation.

Transthyretin (TTR) amyloidosis is a fatal disease for which new therapeutic approaches are urgently needed. We have designed two palindromic ligands, 2,2'-(4,4'-(heptane-1,7-diylbis(oxy))bis(3,5-dichloro-4,1-phenylene)) bis(azanediyl)dibenzoic acid (mds84) and 2,2'-(4,4'-(undeca...

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Bibliographic Details
Main Authors:	Kolstoe, SE, Mangione, P, Bellotti, V, Taylor, G, Tennent, G, Deroo, S, Morrison, A, Cobb, A, Coyne, A, McCammon, MG, Warner, T, Mitchell, J, Gill, R, Smith, M, Ley, S, Robinson, C, Wood, S, Pepys, M
Format:	Journal article
Language:	English
Published:	2010

Trapping of palindromic ligands within native transthyretin prevents amyloid formation.

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